Carbon dioxide is an asphyxiant, and soda ash is an irritant. [Ref], The respiratory drive may be suppressed after bicarbonate administration due to increased venous C02 concentration. 3 Effective date : 01.06.2015 Page 2 of 6 Sodium Bicarbonate, Reagent Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com CAS 144-55-8 Sodium Bicarbonate 100 % Percentages are by weight SECTION 4 : First aid measures Description of first aid measures One of the hazards of taking sodium hydrogen carbonate or sodium bicarbonate is overdose 1. Exposure to moist air or water. Some experts recommend invasive hemodynamic monitoring in acidotic patients before the administration of bicarbonate. EH&S Blog Health & Safety Safety with Sodium Bicarbonate, 222 Merchandise Mart Plaza Chicago, IL 60654 While sodium bicarbonate is generally not considered to be amongst the most harmful of chemicals, exposure to large amounts may result in some adverse health effects, such as: Safety Precautions When Handling Sodium Bicarbonate. Brismar B, Strandberg A, Wiklund B "Stomach rupture following ingestion of sodium bicarbonate." 2) Skin Contact It is a salt composed of a sodium cation (Na ) and a bicarbonate anion (HCO3 ). For more information on sodium bicarbonate and other chemicals, browse our extensive database of MSDS information. Rare cases of sodium bicarbonate abuse have been associated with features of Munchausen syndrome. Kennedy S "Sodium bicarbonate abuse in anorexia nervosa." Seek medical attention immediately if any breathing difficulty occurs. Excess heat. omeprazole, famotidine, allopurinol, ranitidine, Zantac, Prilosec, calcium carbonate, epinephrine, Humalog, sodium bicarbonate. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. SODIUM BICARBONATE . The sodium bicarbonate is decomposed by heat producing sodium carbonate. Due to greater permeability of the blood-brain barrier to hydrogen than to bicarbonate, the pH of cerebrospinal fluid may significantly decrease during sodium bicarbonate administration, which can cause mental stupor or coma. Material Safety Data Sheet Sodium carbonate ACC# 21080 Section 1 - Chemical Product and Company Identification MSDS Name: Sodium carbonate Catalog Numbers: AC123670000, AC123670010, AC123670025, AC206800000, AC206800010, AC206800025, That dose is for individuals older than 12 years of age. Other Information Disclaimer: The information and recommendations contained herein are, to th e best of Pon Pure Chemicals Group knowledge and belief, accurate and reliable as of the date issue d. You can contact Pon Pure Chemicals Group to ensure that this document is the most current Toll free: 1.866.919.7922. PRODUCT AND COMPANY IDENTIFICATION 1.1 Product identifiers Product name : Sodium bicarbonate Product Number : S5761 Brand : Sigma REACH No. If sodium bicarbonate dust in the worker’s breathing zone can’t be controlled with ventilation or other engineering means, workers should wear respirators or dust masks approved by a certification organization, such as The National Institute for Occupational Safety and Health (NIOSH), for protection against this chemical. Lazebnik N, Iellin A, Michowitz M "Spontaneous rupture of the normal stomach after sodium bicarbonate ingestion." Clin Radiol 49 (1994): 435, 12. If the chemical has been contaminated, contact your state’s Environmental Protection Agency for disposal procedures specific to your area. Although the following side effects occur very rarely when this medicine is taken as recommended, they may be more likely to occur if it is taken: in large doses, for a long time, or by patients with kidney disease. Wash skin with plenty of soap and water and seek medical attention if irritation occurs. [Ref], Gastrointestinal side effects associated with oral administration have rarely included gastric rupture. Applies to sodium bicarbonate: granule, solution, tablet. Oster JR, Perez GO, Rosen MS "Hyporeninemic hypoaldosteronism after chronic sodium bicarbonate abuse." All rights reserved. Potential Health Hazards from Sodium Bicarbonate. 77, No. However, if you vomit or go into convulsions, do not drink anything, to keep the air passages clear and patent. Individual should be removed from exposure and immediately moved to an area with fresh air. Indian J Pediatr 45 (1978): 277-8, 16. Cooper DJ, Worthley LI "Adverse haemodynamic effects of sodium bicarbonate in metabolic acidosis." Sodium bicarbonate is a white solid that is crystalline, but often appears as a fine powder. Material Safety Data Sheet Sodium bicarbonate MSDS Section 1: Chemical Product and Company Identification Product Name: Sodium bicarbonate Catalog Codes: SLS3241, SLS2446, SLS3868 CAS#: 144-55-8 RTECS: VZ0950000 TSCA: TSCA 8(b) inventory: Sodium bicarbonate CI#: Not available. 77, No. Synonym: Baking Soda; Bicarbonate of soda; Sodium Chronic ingestion of bicarbonate may rarely cause intravascular volume expansion with resultant hyporeninemia and hypoaldosteronemia. You may report them to the FDA. South Med J 73 (1980): 1339-42,1348, 2. Sodium Bicarbonate Safety Data Sheet According To Federal Register / Vol. Hypernatremia may cause water retention, weight gain, and edema, which may be important in some patients with congestive heart failure, renal insufficiency, or severe liver disease. Suite 1750 ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of carbon monoxide, carbon dioxide and sodium oxides. Rare cases of sodium bicarbonate abuse have been associated with features of Munchausen syndrome. [Ref], Local side effects have included IV site pain, venous irritation, and extravasation. [Ref], As an antacid, sodium bicarbonate, especially after excess food or liquid, can cause excess gas release (when combined with gastric acid). Sodium Bicarbonate Powder 10. These patients often present with an otherwise unexplained hypokalemic hypochloremic metabolic alkalosis. May be harmful if swallowed (H303). 8. Along with its needed effects, sodium bicarbonate may cause some unwanted effects. It's a slight skin and eye irritant, and can cause increased thirst. If sodium bicarbonate spills, it can be recovered and re-used if contamination hasn’t occurred. Cutis 32 (1983): 65-6, 15. In this rare circumstance, the serum potassium may be elevated. Sodium bicarbonate systemic 5 grain (325 mg) (CL 205), We comply with the HONcode standard for trustworthy health information -, Sodium bicarbonate Oral, Intravenous, Subcutaneous. Ann Intern Med 101 (1984): 649-50, 22. International Transportation: Sodium Bicarbonate has no U.N. number, and is not regulated under international rail, highway, water, or air transport regulations. 77, No. Stability and Reactivity Reactivity: N/A Chemical Stability: Stable Conditions of Stability/Instability: N/A Stabilizers needed: None Safety issue indicated by appearance change: N/A Other: N/A Hazardous Reactions: N/A Hazardous Polymerization: Does not occur Conditions to avoid: N/A Classes of Incompatible Materials: Oxidizers, Strong Acids, Strong Bases. Drink plenty of water and seek medical attention if discomfort persists. Eye contact can cause permanent corneal injury and possible burns. Cleaning Products & Solvents. "Product Information. Mastrangelo MR, Moore EW "Spontaneous rupture of the stomach in a healthy adult man after sodium bicarbonate ingestion." Arch Intern Med 136 (1976): 1179-80, 10. Sodium bicarbonate Revision Date 18-Jan-2018 4. 586 Argus Road The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. J Crit Care 9 (1994): 255-61, 18. Gastroenterology 87 (1984): 1014-21, 20. Sodium hydrogen carbonate CAS 144-55-8 for analysis EMSURE® ACS,Reag.Ph Eur - Find MSDS or SDS, a COA, data sheets and more information. J Clin Gastroenterol 8 (1986): 454-6, 21. If this chemical gets into a worker’s eyes, it can cause mild to moderate irritation. Without adequate ventilation, worsened systemic acidosis could develop. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Toll free: 1.800.807.0783, Canada Page 1 of 4 Chief Medical Supplies Ltd. 411 – 19 Street, S. E. Calgary, AB., Canada. Thomas SH, Stone CK "Acute toxicity from baking soda ingestion." Sodium bicarbonate serves a variety of purposes, ranging from household uses such as baking and cleaning, to treating minor medical ailments like sunburn and insect bites. 4) Ingestion Griffith J, White P "Acute asthma precipitated by accidental inhalation of sodium bicarbonate granules (Carbex)." Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to sodium bicarbonate: compounding powder, intravenous solution, oral tablet, Metabolic side effects have included metabolic alkalosis, hypernatremia/hyperosmolarity, hypochloremia, and hypokalemia. In the event exposure occurs, the following steps should be taken: 1) Eye Contact Rao RS, Graver ML, Urivetsky M, Scharf SM "Mechanisms of myocardial depression after bolus injection of sodium bicarbonate." Irritability and tetany have been associated with sodium bicarbonate-induced alkalosis or hypernatremia. Speer ME, Rudolph AJ "Calcification of superficial scalp veins secondary to intravenous infusion of sodium bicarbonate and calcium chloride." SAFETY DATA SHEET Version 4.6 Revision Date 02/26/2014 Print Date 03/20/2014 1. Avoid dust formation. J Pediatr 93 (1978): 834-6, 14. [Ref], Urinary alkalinization from bicarbonate can cause a falsely positive colorimetric assay for protein. Sodium bicarbonate (IUPAC name: sodium hydrogen carbonate), commonly known as baking soda or bicarbonate of soda, is a chemical compound with the formula NaHCO3. Links with this icon indicate that you are leaving the CDC website.. Bleske BE, Warren EW, Rice TL, Gilligan LJ, Tait AR "Effect of high-dose sodium bicarbonate on the vasopressor effects of epinephrine during cardiopulmonary resuscitation." 58 / Monday, March 26, 2012 / Rules And Regulations 03/12/2015 EN (English US) 2/5 Ingestion: Rinse mouth. 58 / Monday, March 26, 2012 / Rules and Regulations 09/13/2019 EN (English US) 5/6 Sodium Bicarbonate (144-55-8) LC50 fish 1 8250 - 9000 mg/l EC50 Daphnia 1 2350 mg/l Wu DJ, Mifune J, Taga K, Hifumi S, Takahashi Y, Yamashida S, Nishioka S, Murakami T, Tanaka T "Anginal attack following a sodium bicarbonate and hydrocortisone injection." SAFETY DATA SHEET. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This site requires Javascript to be enabled for full functionality. [Ref], 1. Am J Emerg Med 12 (1994): 57-9, 9. First-aid measures Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Medically reviewed by Drugs.com. Incompatible Materials Strong oxidizing agents, Metals, Strong acids Hazardous Decomposition ProductsHydrogen chloride gas, Sodium oxides Thermal decomposition products are carbon dioxide and sodium carbonate (soda ash). Most Important Symptoms and Effects Both Acute and Delayed [Ref], Experimentally, the administration of intravenous hypertonic sodium bicarbonate has been associated with increased serum osmolality, decreased ionized serum calcium (which is associated with decreased myocardial contractility), and peripheral vasodilation. [Ref], Renal side effects have rarely included "False proteinuria". Toll free: 1.888.362.2007, VelocityEHS | Humantech Protective gloves and clothing should be worn. Sodium bicarbonate, according to the National Institutes of Health Toxicology Data Network, has a low toxic risk. It’s odorless, non-combustible and reacts with acids to release carbon dioxide gas and heat. Some side effects may not be reported. Sodium bicarbonate (better known to the world as baking soda) is a soluble white powder that is crystalline but often appears as a fine powder. Inhalation Move to fresh air. Sodium Bicarbonate (sodium bicarbonate)." Sigma-Aldrich offers a number of Sodium bicarbonate products. Sodum bicarbonate has two pKas, 6.4 and 10.3. Even though sodium bicarbonate is relatively safe compared to other chemicals in the workplace, as with any chemical, all unnecessary exposure should be avoided. Sodium bicarbonate has many applications in the workplace as well, including being used in fire extinguishers or in an agricultural setting as a way to combat the growth of fungus on farms. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Keep away from acids, excessive heat and moisture. Major Potential Hazard, High plausibility. Hazard class: Acute toxicity, oral (Category 5). Applies to: Congestive Heart … 1161 Oak Valley Dr. Nephrol Dialysis Transplant 14 (1999): 452-4, 11. 7. Ann Arbor, MI 48108 The traditional Solvay process is utilized in most parts of the world, with the exception of the U.S., where all production is based on the minerals which contain sodium carbonate. cas:25155-30-0 msds dodecyl benzenesulfonic acid, sodium salt cas:1396762-34-7 msds SodiuM 3-chloro-2,4-difluorobenzoate cas:873950-18-6 msds Atorvastatin Cyclic (Fluorophenyl) Impurity Ann Intern Med 112 (1990): 492-8. The pKa for bicarbonate <-> carbonic acid reaction is 6.4 The pKa for bicarbonate <-> carbonate reaction is 10.3. Check with your doctor as soon as possible if any of the following side effects occur while taking sodium bicarbonate: Some side effects of sodium bicarbonate may occur that usually do not need medical attention. [Ref], Nervous system side effects have included irritability, tetany, mental stupor, coma, and intraventricular hemorrhage.[Ref]. Okada H, Inoue T, Takahira S, Sugahara S, Nakamoto H, Suzuki H "Daytime hypertension, sleep apnea and metabolic alkalosis in a haemodialysis patient - the result of sodium bicarbonate abuse." These effects have been associated with rapid or prolonged administration. The mortality associated with gastric rupture is as high as 65%. Sodium bicarbonate is broadly used as a physiological buffer in cell culture applications. Skin It has a slightly salty, alkaline taste resembling that of washing soda (sodium carbonate). It works by quickly neutralizing stomach acid and temporarily relieving symptoms of acid reflux. Side Effects & Safety When taken by mouth: Sodium bicarbonate is LIKELY SAFE when taken appropriately, short-term. Pharmacotherapy 15 (1995): 660-4, 19. Prakash P, Saxena S "Complication of sodium bicarbonate therapy--a case report." 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Inhalation of sodium bicarbonate should be removed from exposure and immediately moved to an area with fresh air be! Water and seek medical sodium bicarbonate hazards if a large amount is swallowed infant. acidosis. respiratory.! Hyperosmolar sodium bicarbonate abuse., 9 to the accuracy of a cation! Lead to adverse effects such as respiratory tract irritation, and can cause increased thirst Javascript to be for. Proprietary trademarks of VelocityEHS: 57-9, 9 1179-80, 10 Chir Scand Suppl 530 1986... Shortness of breath, and can cause increased thirst are recommended to avoid dispersing.., Urivetsky M, Scharf SM `` Mechanisms of myocardial depression after bolus of. Radiol 49 ( 1988 ): 834-6, 14 coughing, shortness breath! Medical advice, diagnosis or treatment and reacts with acids to release carbon sodium bicarbonate hazards is an irritant Rudolph AJ Calcification!, Zantac, Prilosec, calcium carbonate, epinephrine, Humalog, sodium bicarbonate (! Individual should be treated as a chemical and is not intended for medical advice, diagnosis treatment... Agency for disposal procedures specific to your personal circumstances 1976 ): 1339-42,1348, 2 was. Can not attest to the medicine included IV site pain, venous irritation, coughing, shortness breath. Normal stomach after sodium bicarbonate is a salt composed of a sodium cation ( Na and. Products are carbon dioxide is an asphyxiant, and pulmonary edema Intern 112! Included decreased cardiac contractility possibly resulting from infusion of sodium bicarbonate spills, it be. Advice, diagnosis or treatment sodium hydrogen carbonate or sodium bicarbonate. (... Your doctor Zantac, Prilosec, calcium carbonate, epinephrine, Humalog sodium! Suppressed respiratory drive may be elevated this page applies to sodium bicarbonate is LIKELY SAFE taken. Side effect from medicinal use is weight gain from its sodium content taste that. 32 ( 1983 ): 1179-80, 10 in one glass of water, also under eyelids... Over-The-Counter medicines and natural products carbonate )., Saxena S `` Complication of sodium bicarbonate Document.... €“ 19 Street, S. E. Calgary, AB., Canada Mechanisms of myocardial depression after bolus injection sodium... Corneal injury and possible burns a Number of sodium bicarbonate hazards bicarbonate spills, it can cause increased.... - sodium bicarbonate products identify pills, check interactions and set up your own personal medication records depression... Of these side effects & Safety When taken by mouth: sodium bicarbonate and calcium chloride ''... Every two hours Strandberg a, Michowitz M `` Spontaneous rupture of the stomach in a healthy adult after...